The following Americans have entered into the second round:
- Mardy Fish - still the USA's best hope to win by far
- Alex Bogomolov, Jr - needed five sets to defeat fellow American Steve Johnson (this year's NCAA men's singles champion; a senior at USC)
- John Isner - had a 141 mph serve in his match; second round match is against Ginepri
- Robby Ginepri - wild card entrant; made it to the semi-finals of the Open in 2005
- Donald Young - a straight sets victory; first win at the US Open in 4 years
- James Blake - Has had a rough year, but this is a good start to the Open; second round match is against #5 seed David Ferrer
- Jack Sock - the 18-year-old starts his first major senior Grand Slam with a win; unfortunately his second round opponent is likely to be:
- Andy Roddick - currently winning 2 sets to one; up in the fourth set 2-1 against fellow American Michael Russell